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If a function is not accessible, the pump ignores the key press and a beep does not sound. Number of participants: number randomized not specified, 106 evaluated. Adverse Reactions In clinical studies the overall discontinuation rate related to Apraclonidine ophthalmic solution was 15% lire ici. Yes, some antihistamines, such as diphenhydramine, do cause constipation as a side effect.